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"Normalization of brachial artery flow-mediated dilation (FMD) to individual shear stress area under the curve (peak FMD: SSAUC ratio) has recently been proposed as an approach to control for the large inter- subject variability in reactive hyperemia- induced shear stress; however, the adoption of this approach among researchers has been slow. The present study was designed to further examine the efficacy of FMD normalization to shear stress in reducing measurement variability," scientists in the United States report (see also Hyperemia).
"Five different magnitudes of reactive hyperemia- induced shear stress were applied to 20 healthy, physically active young adults (25.3 +/- 0. 6 yrs; 10 men, 10 women) by manipulating forearm cuff occlusion duration: 1, 2, 3, 4, and 5 min, in a randomized order. A venous blood draw was performed for determination of baseline whole blood viscosity and hematocrit. The magnitude of occlusion- induced forearm ischemia was quantified by dual- wavelength near- infrared spectrometry (NIRS). Brachial artery diameters and velocities were obtained via high- resolution ultrasound. The SSAUC was individually calculated for the duration of time- to- peak dilation. One- way repeated measures ANOVA demonstrated distinct magnitudes of occlusioninduced ischemia (volume and peak), hyperemic shear ...
Source: HighBeam Research, Research from Indiana University in the area of hyperemia published.