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<a href="http://www.accessmylibrary.com/article-1G1-189217546/scientists-tarbiat-modares-university.html" title="Facts and information about Scientists at Tarbiat Modares University release new data on immunotherapy.">Scientists at Tarbiat Modares University release new data on immunotherapy.</a>
Scientists at Tarbiat Modares University release new data on immunotherapy.
Women's Health Weekly
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November 06, 2008 |
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In this recently published study, investigators in Iran conducted a study "To investigate the immunomodulatory activity of decidual culture supernatant on dendritic cell (DC) functions. In vivo and in vitro experimental study using mice."
"Academic research laboratory. Animal(s): C57BL/6-mated female Balb/c mice. Culture supernatants of decidual cells obtained from the uteri of allogenic pregnant mice (Balb/c x C57BL/6) were collected. Dendritic cells were purified from Balb/c mice spleens and pulsed with antigen during overnight culture. In some cultures, decidual supernatant was added at 5%, 10%, or 20% final concentration. Endometrial culture supernatant-treated DCs served as a control. Antigen-pulsed DCs were injected into the front footpads of syngeneic mice. Lymph nodes of primed mice were removed 5 days after DC injection. Antigen-specific proliferation and interleukin-10 and interferon gamma production by lymphocytes were measured by H-3-Thymidine incorporation and ELISA, respectively. The results showed that decidual culture supernatant markedly blocked in vivo antigen presentation by DCs and inhibited their capacity to induce interferon gamma (but not interleukin-10) production by primed lymphocytes," wrote A.H. Zarnani and colleagues, Tarbiat ...
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