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Research in the area of hormones reported from R.B. Deaguiar and colleagues.(Report)
"Estrogen compounds have been described as important brain protectors. This study investigated the effects of estradiol valerate (EV-0.3 mg/kg) and two concentrations of tibolone (TB1 = 0.5 mg/kg and TB2 = 1 mg/kg) on brain oxidative stress parameters and blood biochemistry in ovariectomized female rats, of three different age groups (young-2 months, adult-8 months, and old-20 months)," scientists in Rio Grande, Brazil report (see also Hormones).
"In the brain cortex, young and old TB2-treated and old no-hormone-replacement (NR) females showed lower lipid hydroperoxide (LPO) levels compared to young Sham and adult TB1 animals (P
The researchers concluded: "These results suggest that the effects of gonad steroid on brain and blood physiology change significantly with aging, and that evaluating hormonal treatment types and doses could be the key factor in the potential use of a specific hormone therapy."
Deaguiar and colleagues published their study in Biogerontology (Estradiol valerate and tibolone: effects upon brain oxidative stress and blood biochemistry during aging in female rats. Biogerontology, 2008;9(5):285-298).
For more information, contact P.E. Martinez, Fundacao University Fed Rio Grande, Programa Posgrad Ciencias Fisiol Fisiol Animal Computational, Av Italia, Km 8, S-N, Cx Postal 474, BR-96201900 Rio Grande, RS, Brazil.
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Source: HighBeam Research, Research in the area of hormones reported from R.B. Deaguiar and...