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Data from A. Sato and colleagues advance knowledge in cardiology.(Report)
According to recent research from Kanagawa, Japan, "This study was designed to assess the influence of coronary endothelial function and the serial changes of dual myocardial single photon emission computed tomography (SPECT) imaging in transient left ventricular (LV) apical ballooning. We evaluated 35 consecutive patients (8 men and 27 women; mean age, 71 +/- 13 years) with transient LV apical ballooning."
"All patients underwent coronary angiography with acetylcholine provocation I month after onset. Iodine 123 beta-methyl-piodophenyl-pentadecanoic acid (BMIPP) and thallium 201 dual myocardial SPECT was serially performed on day 1 of admission and 1 month and 6 months later. In 8 of 35 patients (23%), epicardial coronary spasm was induced by acetylcholine infusion. At the peak acetylcholine dose (100 mu g), diffuse coronary vasoconstriction developed in 19 of 35 patients (54%). Of 19 patients, 13 had diffuse coronary vasoconstriction with chest pain and ST-segment depression. The total defect score of I-123 BMIPP and TI-201 SPECT showed marked perfusion-fatty acid metabolic mismatches (13.7 +/- 3.6 vs 8.7 +/- 2.3, P
The researchers ...
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