Reports from Columbia University describe recent advances in bone research.(Report)

"Osteoporosis is a major public health problem in men. Hypogonadal men have decreased BMD and deteriorated trabecular bone architecture compared with eugonadal men," scientists in the United States report (see also Bone Research).

"Testosterone treatment improves their BMD and trabecular structure. We tested the hypothesis that testosterone replacement in hypogonadal men would also improve their bone's mechanical properties. Ten untreated severely hypogonadal and 10 eugonadal men were selected. The hypogonadal men were treated with a testosterone gel for 24 mo to maintain their serum testosterone concentrations within the normal range. Each subject was assessed before and after 6, 12, and 24 mo of testosterone treatment by mu MRI of the distal tibia. A subvolume of each mu MR image was converted to a microfinite element (mu FE) model, and six analyses were performed, representing three compression and three shear tests. The anisotropic stiffness tensor was calculated. from which the orthotropic elastic material constants were derived. Changes in microarchitecture were also quantified using newly developed individual trabeculae segmentation (ITS)-based and standard morphological analyses. The accuracy of these techniques was examined with simulated mu MR Images. Significant differences in four estimated anisotropic elastic material constants and most morphological parameters were detected between the eugonadal and hypogonadal men. No significant change in estimated elastic moduli and morphological parameters was detected in the eugonadal group over 24 mo. After 24 mo of treatment, significant increases in estimated elastic moduli E-22 (9.0%), E-33 (5.1%), G(23) (7.2%), and G(12) (9.4%) of hypogonadal men were ...