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Studies from F.L. Queiroga and colleagues provide new data on hormones.
According to a study from Vila Real, Portugal, "Growth hormone (GH), insulin-like growth factor I (IGF-I), progesterone (P4) and 17 beta-estradiol (17-E2) concentrations have been studied in 84 mammary tumours (44 dysplasias and benign tumours and 40 malignant neoplasias) from 33 female dogs. Thirteen normal mammary glands from 80 healthy female dogs were also analysed as controls."
"GH concentrations were determined in mammary homogenates by radio-immunoassay. IGF-I, P4 and 17-E2 tissue levels were determined by enzyme-immunoassay (EIA) techniques. The potential correlations between GH/IGF-I concentrations and P4 and 17-E2 mammary tissue levels were investigated. Tissue GH (p
The researchers concluded: "These results suggest that all these hormones and factors might act as local growth factors stimulating the development and/or maintenance of canine mammary tumours in an autocrine/paracrine manner."
Queiroga and colleagues published the results of their research in the Journal of Steroid Biochemistry and Molecular Biology (Crosstalk between GH/IGF-I axis and steroid hormones (Progesterone, 17 beta-estradiol) in canine mammary tumours. Journal of Steroid Biochemistry and Molecular Biology, 2008;110(1-2):76-82).
For additional information, contact F.L. Queiroga, University of Tras Montes & Alto Douro, Dept. of Vet. Science, CECAV, P-5001801 Vila Real, Portugal.
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