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Study results from R.D. Soares and colleagues broaden understanding of ectopic pregnancy.(Clinical report)

Women's Health Weekly

| October 02, 2008 | COPYRIGHT 2008 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

According to recent research from Salvador, Brazil, " To evaluate the increment in beta-hCG levels (%) in the 48-h interval prior to treatment as a predictor of therapeutic success in the management of ectopic pregnancy with methotrexate. A prospective observational study was carried out between April 2002 and November 2006 at the Federal University of Sao Paulo in 65 patients with an ectopic pregnancy treated with a single dose of 50 mg/m(2) of methotrexate administered intramuscularly."

"The following predictive factors were evaluated: beta-hCG level on the day of hospital admission and the percent increment in beta-hCG in the 48-h interval prior to treatment. Treatment was successful in 49 cases (75.4%). In these cases, beta-hCG levels at hospitalization were lower when compared to the levels found in cases of therapeutic failure (1,928.9 vs. 4,828.6 mIU/ml, respectively; P

The researchers concluded: "The margin of safety for treatment with methotrexate is high when beta-hCG measurement on the day of hospitalization is

Soares and colleagues published their study in Archives of Gynecology and Obstetrics (Increment in beta-hCG in the 48-h period prior to treatment: a new variable predictive of therapeutic success in the treatment of ectopic pregnancy with methotrexate. Archives of Gynecology and Obstetrics, 2008;278(4):319-324).

For additional information, contact R.D. ...

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