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Research from G. Fatemeh and colleagues provide new insights into drug resistance.
"Background and goals This study is designed to survey gestational trophoblastic neoplasia with vaginal metastases (GTN + VM) manifestations, prognosis and chemotherapy response in order to consider appropriate chemotherapy regimen for these patients. There have been just a few studies about treatment of GTN + VM," investigators in Iran report (see also Drug Resistance).
"Materials and methods Patients with Stage III GTN with or without vaginal metastases who had referred to Vali-e-Asr Hospital during 1996-2006 have been selected to take part in this study and the size of metastases was measured. Then response and resistance to single and combination chemotherapy regimens have been compared in these two groups. The data were processed using SPSS system (release 10). Statistical analysis was done with X-2 to determine factors associated with complete clinical response. The level of significance was assigned at P
The researchers concluded: "There have higher risks for severe hemorrhage and resistance to single agent chemotherapy, so in these patients combination chemotherapy, with no regard to staging and scoring, would be a better choice."
Fatemeh and colleagues published their study in Archives of Gynecology and Obstetrics (Assessment of the response to chemotherapy in gestational trophoblastic neoplasia with vaginal metastases. Archives of Gynecology and Obstetrics, 2008;278(4):315-318).
For additional information, contact G. Fatemeh, Vali e Asr Hospital, Dept. of Gynecology Oncology, Imam Khomeinis Hospital Complex, Keshavarz Blvd., Tehran, Iran.
The publisher of the journal Archives of Gynecology and Obstetrics can be contacted at: Springer ...
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