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Studies from Meharry Medical College, Medical College have provided new information about endometriosis.(Report)
"The purpose of this study was to screen a panel of targeted adenoviruses as vectors for endometriosis gene therapy. Endometriotic cells were obtained from subjects with ovarian endometriomas," scientists in the United States report (see also Endometriosis).
"Liver tissues were taken from donors during hepatic transplantation surgery. Human endometriotic cells and liver tissues were transfected by targeted adenoviruses expressing luciferase reporter gene. Luciferase activity that was mediated by each virus was expressed as a percentage of adenovirus serotype 5 (Ad5-CMV-luc) activity. The 2-tailed Studentt test was used to compare the adenovirus data," wrote E.E.R. Othman and colleagues, Meharry Medical College, Medical College.
The researchers concluded: "In endometriotic cells, the adenovirus-RGD (Ad-RGD-luc), adenovirus under secretory leukocyte protease inhibitor promoter (Ad-SLPI-luc), and adenovirus under heparanase promoter (Ad-heparanase-luc) showed significantly higher activity, compared with the adenovirus serotype 5. In liver tissues, adenovirus-survivin (Ad-survivin-luc) and Ad-heparanase-luc had significantly lower activity, compared with ...
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Source: HighBeam Research, Studies from Meharry Medical College, Medical College have provided...