AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Researchers from University of Tokyo describe findings in endometriosis.(Report)
"Several lines of evidence indicate that the Th2 immune response is associated with endometriosis. Although an increased concentration of interleukin (IL)-4, a typical Th2 cytokine, has been reported in endometriotic tissues, the implication of this for endometriosis has not been determined," scientists in Hongo, Japan report (see also Endometriosis).
"To investigate a possible role of IL-4 in the development of endometriosis, we examined the presence of IL-4-producing cells in endometriotic tissues and the effect of IL-4 on proliferation of endometriotic stromal cells. Endometriotic stromal cells were isolated from endometriotic tissues obtained from women undergoing surgery for endometrioma. Immunohistochemistry of endometriotic tissues revealed that IL-4-positive cells were abundant in the stroma. The effect of IL-4 on proliferation of endometriotic stromal cells was studied using cell counting and BrdU incorporation assays. IL-4 (0.1 to 10 ng/ml) significantly increased cell number and BrdU incorporation in a dose-dependent manner, and the proliferative effect of IL-4 was inhibited by anti-IL-4 receptor antibody. IL-4-induced activation of mitogen-activated protein kinases in endometriotic stromal cells was examined by Western blotting. IL-4 induced phosphorylation of p38 mitogen-activated protein kinase, ...
- Data from Northwestern University, Medical Department advance knowledge in...
- Magazine article from: Women's Health Weekly March 26, 2009 700+ words
...high levels of ER beta in endometriotic stromal cells from ovarian endometriomas...mRNA and protein levels in endometriotic stromal cells. Conversely, ER...contribute to proliferation of endometriotic stromal cells. We speculate that...St. 4-123, Chicago, IL 60611, USA. ...
- Findings from Tottori University, Medical Department advance knowledge in...
- Magazine article from: Women's Health Weekly November 27, 2008 700+ words
...whether serum interleukin (IL)-8 concentration can be...blood samples were obtained. Endometriotic stromal cells obtained from nine patients...The serum concentration of IL-8 inpatients with endometrioma...benign ovarian cyst. The serum IL-8 threshold (25 pg/mL...
- Research on life sciences reported by scientists at Shandong University.(Report)
- Magazine article from: Women's Health Weekly October 1, 2009 700+ words
Research findings, 'Endometriotic stromal cells lose the ability...from normal or eutopic endometriotic stromal cells significantly inhibited...However, CM from ectopic endometriotic stromal cells did not have an...
- Data from Emory University, Medical Department provide new insights into...
- Magazine article from: Women's Health Weekly October 1, 2009 700+ words
...expression and secretion in endometriotic stromal cells in vitro. Isolated...eutopic, and ectopic endometriotic stromal cells were cultured...eutopic, and ectopic endometriotic stromal cells. 3H-Thymidine...
- Researchers at National Cheng-Kung University, Medical Department target life...
- Magazine article from: Women's Health Weekly September 4, 2008 700+ words
...regulatory (StAR) protein in human endometriotic stromal cells plays an important role in...cooperative manner in ectopic human endometriotic stromal cells, providing a molecular framework...regulatory protein expression in endometriotic stromal cells. American Journal of Pathology...
- New endometriosis study findings have been published by scientists at Yale...
- Magazine article from: Women's Health Weekly October 9, 2008 700+ words
...lt;0.05). In endometriotic glandular cells, there was no cyclical variation in phospho-ERK1/2. In endometriotic stromal cells, there was also a reduction in phospho-ERK1/2 variation, with higher levels in the early-mid secretory...
- The IL-23/IL-17 axis in inflammation.(commentaries)(medical research)
- Magazine article from: Journal of Clinical Investigation Iwakura, Yoichiro Ishigame, Harumichi May 1, 2006 700+ words
IL-23 induces the differentiation of naive [CD4.sup.+] T cells into highly pathogenic helper T cells (Th17/[Th.sub.IL-17]) that produce IL-17, IL-17F, IL-6, and TNF-[alpha], but not IFN-[gamma...
- The IL-21 receptor augments Th2 effector function and alternative macrophage...
- Magazine article from: Journal of Clinical Investigation Pesce, John Kaviratne, Mallika Ramalingam, Thirumalai R. Thompson, Robert W. Urban, Joseph F., Jr. Cheever, Allen W. Young, Deborah A. Collins, Mary Grusby, Michael J. Wynn, Thomas A. July 1, 2006 700+ words
The IL-21 receptor (IL-21R) shows significant homology with the IL-4R, and CD[4.sup.+] Th2 cells are an important source of IL-21. Here we examined whether the IL-21R regulates the development of Th2 responses in vivo. To do...