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Study findings from Mayo Clinic broaden understanding of atrial fibrillation.
According to a study from the United States, "Gender and Lone AF. Epidemiological studies report a male predominance in lone atrial fibrillation (LAF)."
"Phenotypic differences between sporadic and familial LAF could aid in deciding which cases should undergo family screening. We sought to determine gender distribution in sporadic and familial LAF, gender-based differences, and phenotypic differences between sporadic and familial LAF. Since November 2000, 192 unrelated LAF probands were recruited. Sporadic LAF was defined as the absence of a family history of LAF. Familial LAF was classified as possible if one first- or second-degree relative had LAF, or confirmed if >= 2 relatives had LAF. Affected relatives (n = 87) of 34 confirmed familial probands were also evaluated. For unrelated LAF probands, differences in proportions and means were tested using chi(2) and ANOVA, respectively. Difference in gender ratio among the family history groups was tested using mixed models. Male proportion was greater among sporadic (82%) and possible familial probands (84%) than confirmed familial probands (62%), and affected relatives (54%), P
The researchers concluded: "Finally, sporadic and familial LAF are clinically indistinguishable."
Chen and colleagues published the results of their research in the Journal of Cardiovascular Electrophysiology (Lone atrial fibrillation: Influence of familial disease on gender predilection. Journal of Cardiovascular ...
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