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Scientists at University of Oulu, Department of Medical Microbiology publish research in chlamydia.(Report)
Research findings, 'Selective cyclooxygenase inhibitors prevent the growth of Chlamydia pneumoniae in HL cells,' are discussed in a new report. "The effects of the selective cyclooxygenase (COX) inhibitors SC-560 and PTPBS were studied in Chlamydia pneumoniae-infected HL cell cultures. Chlamydia pneumoniae growth and viability were assessed by quantifying inclusions and re-passages. COX-1 and COX-2 mRNA expression in HL cells during chlamydial infection was quantified with real-time polymerase chain reaction," scientists in Oulu, Finland report (see also Chlamydia).
"SC-560 (10 microg/mL) and PTPBS (18 microg/mL) completely inhibited the growth of C. pneumoniae and the effect was dose-dependent between 4-9 microg/mL and 2-16 microg/mL, respectively. Inclusion size was reduced from 11.5[+ or -]1.3 microm to 1.9[+ or -]0.7 microm in the presence of the drugs. Removing the drugs returned the size to normal and increased the number of inclusions," wrote Y. Yan and colleagues, University of Oulu, Department of Medical Microbiology.
The researchers concluded: "Selective COX inhibitors appear to have a chlamydiostatic but ...
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Source: HighBeam Research, Scientists at University of Oulu, Department of Medical Microbiology...