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New data from Keimyung University, Medical Department illuminate research in apoptosis.(Report)
According to recent research from South Korea, "Sanguinarine is a benzophenanthridine alkaloid derived from the root of Sanguinaria canadensis and other poppy-fumaria species, possessing potent antibacterial, antifungal, and anti-inflammatory activities. In this study, we investigated the underling mechanisms by which sanguinarine induce apoptosis in human breast cancer MDA-231 cells."
"Treatment of MDA-231 cells with sanguinarine induced remarkable apoptosis accompanying the generation of ROS. Consistently, sanguinarine-induced apoptosis was mediated by the increased reproductive cell death. Pretreatment with NAC or GSH attenuated sanguinarine-induced apoptosis, suggesting the involvement of ROS in this cell death. During sanguinarin-induced apoptosis, protein levels of pro-caspase-3, Bcl-2, cIAP2, XIAP, and c-FLIPs were reduced. Sanguinarine-mediated apoptosis was substantially blocked by ectopic expression of Bcl-2 and cFLIPs. Additionally, we found that sub-lethal doses of sanguinarine remarkably sensitized breast cancer cells to TRAIL-mediated apoptosis, but the cell death induced by sanguinarine and TRAIL in combination was not blocked by overexpression of Bcl-2 or Akt," wrote S. Kim and ...
- Keimyung University, Medical Department details research in apoptosis.
- Newspaper article from: Angiogenesis Weekly January 23, 2009 700+ words
...wrote J. Oh and colleagues, Keimyung University, Medical Department. The researchers...obtained by contacting T. Kwon, Keimyung University, School Medical, Dept. of Immunology...Oncology, Tumor Vascularization, Keimyung University, Medical Department. This article...
- Studies from Keimyung University further understanding of thyroid cancer.
- Newspaper article from: Cancer Weekly July 21, 2009 700+ words
...wrote S.K. Lee and colleagues, Keimyung University (see also Thyroid Cancer). The...information, contact S.K. Lee, Keimyung University, College Medical, Dongsan Med...Thyroid Neoplasms, Thyroiditis, Keimyung University. This article was prepared by Cancer...
- Researchers from Keimyung University, Medical Department report recent findings...
- Newspaper article from: Angiogenesis Weekly June 19, 2009 700+ words
...wrote J.W. Park and colleagues, Keimyung University, Medical Department. The researchers...information, contact W.K. Baek, Keimyung University, School Medical, Dept. of Microbiology...Neoplasms, Tumor Vascularization, Keimyung University, Medical Department. This article...
- Studies from Keimyung University in the area of hepatocellular cancer published.
- Newspaper article from: Cancer Weekly October 27, 2009 700+ words
...wrote K.W. Jung and colleagues, Keimyung University. The researchers concluded...information, contact J.S. Hwang, Keimyung University, Dept. of Internal Medical, School...Carcinoma, Necrosis, Oncology, Keimyung University. This article was prepared by Cancer...
- Researchers at Keimyung University release new data on echocardiography.(Report)
- Newspaper article from: Biotech Week September 10, 2008 700+ words
...wrote H. Kim and colleagues, Keimyung University (see also Echocardiography...information, contact H. Kim, Keimyung University, Dongsan Med Center, Division...Echocardiography, Hypertension, Hypertrophy, Keimyung University. This article was prepared by Biotech...
- Research from Keimyung University reveals new findings on salivary gland...
- Newspaper article from: Cancer Weekly September 15, 2009 700+ words
...wrote S.K. Lee and colleagues, Keimyung University. The researchers concluded...information, contact S.K. Lee, Keimyung University, Dept. of Radiol, Dongsan Med...Salivary Gland Disease, Surgery, Keimyung University. This article was prepared by Cancer...
- Researchers from Keimyung University detail new studies and findings in the...
- Newspaper article from: Blood Weekly August 21, 2008 700+ words
...wrote J.H. Jang and colleagues, Keimyung University (see also Ischemia). The researchers...information, contact K.J. Kang, Keimyung University, Division Hepatobiliary &...Transplant, Surgery, Transplantation, Keimyung University. This article was prepared by Blood...
- Researchers at Keimyung University, Medical Department have published new data...
- Newspaper article from: Biotech Week August 6, 2008 700+ words
...wrote S.H. Park and colleagues, Keimyung University, Medical Department. The researchers...information, contact D.K. Song, Keimyung University, School Medical, Dept. of Physiol...Gynecology, Leiomyoma, Polymerase, Keimyung University, Medical Department. This article...
Source: HighBeam Research, New data from Keimyung University, Medical Department illuminate...