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According to a study from Oslo, Norway, " The etiology of Hyperemesis gravidarum (HG) is unclear. To test the hypothesis of an association between Helicobacter pylori infection and HG, an institution-based case-control study was performed at Aker University Hospital (AUH) during 1994-1999."
"Material and method From the same source population, 244 incident cases of HG and 244 pregnant women free of the disease (controls) were consecutively identified. H. pylori were noted in 105 cases and 58 control subjects. The presence of H. pylori increased the risk of HG more than two fold (OR = 2.42, 95% CI: 1.64-3.57, P
The researchers concluded: " These results indicate that H. pylori increase the risk of HG with a dose-response pattern and stronger in Africans."
Sandven and colleagues published their study in European Journal of Epidemiology (Helicobacter pylori infection and Hyperemesis gravidarum. An institution-based case-control study. European Journal of Epidemiology, 2008;23(7):491-498).
For more information, contact I. Sandven, Ullevaal University Hospital, Clinic Research Center, ...