Reports on endometriosis findings from A. Akoum and co-researchers provide new insights.(Report)

In this recent report published in the journal Fertility and Sterility, researchers in Canada conducted a study "To evaluate the levels of interleukin-1 beta (IL1 beta) and its inhibitory soluble interleukin-1 receptor type II (IL1R2) in the peritoneal fluid (PF) of normal women and patients with endometriosis suffering from pelvic pain and infertility. Retrospective study using ELISA to measure peritoneal fluid IL1 beta and soluble IL1R2."

"Gynecology clinic and human reproduction research laboratory. Sixty-eight normal women and 154 women with endometriosis. Peritoneal fluid samples were obtained at laparoscopy. IL1 beta and soluble IL1R2 concentrations in the PF samples. Result(S): This study showed a marked decrease in peritoneal soluble IL1R2 levels in women with endometriosis compared to normal women and a concomitant increase in the levels of IL1 beta. Both fertile and infertile women with endometriosis had lower soluble IL1R2 and higher IL1 beta concentrations than fertile women having a normal gynecological status, but the difference was more significant in infertile endometriosis patients. Compared with normal controls, the decrease in soluble IL1R2 levels was less significant in women with endometriosis than without pelvic pain, whereas the increase in IL1 beta concentrations was statistically significant only in women with endometriosis reporting pelvic pain," wrote A. Akoum and colleagues ...