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Reports on Down syndrome findings from G.M. Lambertmesserlian and co-researchers provide new insights.(Report)
According to recent research from the United States, " Second-trimester measurement of maternal serum inhibin A is widely used for Down syndrome screening. To date, only a manual enzyme-linked immunosorbent assay (ELISA) produced by Diagnostic Systems Laboratories, Inc (DSL) has been available."
"The objective of this study was to compare the DSL assay with a new automated assay produced by Beckman Coulter, Inc (Access). Residual serum samples from 570 women, who were receiving routine screening for Down syndrome, were retrieved from storage. The Access assay sensitivity, linearity and reproducibility were determined and a method comparison was performed. Inhibin A levels were measured using both assays. Twenty samples from women with confirmed Down syndrome pregnancy were also tested. The Access assay had coefficients of variation of less than 10% across the range of values tested, and a sensitivity below 1 pg/mL. The DSL and Access inhibin A assay values were highly correlated (r = 0.961, r(2) = 0.923), with no apparent outliers. Inhibin A values from the Access assay were a constant 23% lower (95% CI 1-41%) than corresponding values from the DSL assay. Median values from 15 to 20 completed weeks' gestation were computed and found to be consistent with expectations. The weight-adjusted multiples of the median (MoM) levels in the unaffected pregnancies fit a log Gaussian distribution well between at least the 5th and 95th percentiles with corresponding log ...
- REPRODUCTIVE DECISIONS AFTER PRENATAL DIAGNOSIS IN NEUROFIBROMATOSIS TYPE 1:...
- Magazine article from: Genetic Counseling Terzi, Y K; Oguzkan-Balci, S; Anlar, B; Aysun, S; Guran, S; Ayter, S April 1, 2009 700+ words
...Summary: Reproductive decisions after prenatal diagnosis in neurofibromatosis type 1: importance...NF1 gene allows presymptomatic and prenatal diagnosis, but is complex and time-consuming...Because the time for investigations in prenatal diagnosis is restricted, detection of ...
- Prenatal diagnosis of monosomy 18p reported.
- Newspaper article from: Genomics & Genetics Weekly May 28, 2004 700+ words
...com & NewsRx.net) -- Prenatal diagnosis of monosomy 18p based on amniocentesis...Scientists writing in the journal Prenatal Diagnosis, "report a de novo translocation...and 18 resulting in monosomy 18p in prenatal diagnosis. The patient was referred for amniocentesis...
- Microarray analysis improves prenatal diagnosis.
- Magazine article from: Women's Health Weekly December 4, 2008 700+ words
...abnormalities proved an effective tool in prenatal diagnosis in a series of 300 cases at Baylor...the current issue of the journal Prenatal Diagnosis (see also Baylor College of Medicine...with an ultrasound or other means of prenatal diagnosis, she said. "This test adds ...
- DNA screening useful for prenatal diagnosis of congenital toxoplasmosis.
- Magazine article from: Women's Health Weekly February 13, 2003 700+ words
...seroconversion during pregnancy underwent prenatal diagnosis of fetal toxoplasmosis. The following...combination of both tests allowed the prenatal diagnosis in 17/18 infected fetuses (94...published the results of their study in Prenatal Diagnosis (Prenatal diagnosis ...
- Prenatal diagnosis impacts the parental psyche.
- Newspaper article from: Medical Devices & Surgical Technology Week February 15, 2004 700+ words
...com & NewsRx.net) -- Prenatal diagnosis impacts the parental psyche. According...Gynakologe, "prior to a specific prenatal diagnosis, the pregnant woman should receive...availability of noninvasive techniques for prenatal diagnosis seems to have led to a higher level...
- PRENATAL DIAGNOSIS TESTS CAN FORETELL ONE'S GENETIC DESTINY
- Newspaper article from: The Boston Globe Richard Saltus, Globe Staff July 20, 1987 700+ words
...recurrence of the syndrome would be prenatal diagnosis. But could they face aborting an...genetic disorders. In most cases, prenatal diagnosis has given reassurance to parents...struggle." Deciding how to act on a prenatal diagnosis, as hard as it is now, will become...
- Fetal age has little influence on parental stress during prenatal diagnosis.
- Newspaper article from: Medical Devices & Surgical Technology Week February 29, 2004 700+ words
...little influence on parental stress during prenatal diagnosis. "Prenatal diagnosis is usually performed in the early weeks...regard to the week of gestation in which the prenatal diagnosis was made. In total, 452 pregnant women...
- Prenatal Diagnosis of Heart Defect May Reduce Seizures and Coma in Newborns,...
- Press release article from: PR Newswire June 4, 2001 700+ words
...defects before birth, although whether prenatal diagnosis benefits children with heart disease...to examine an association between prenatal diagnosis and early neurological events. We...Mahle. "We hope to show that prenatal diagnosis, in addition to reducing short...
