Recent findings from S. Yasar and co-authors highlight research in angiotensins.

According to a study from the United States, "The effects of angiotensin-converting enzyme inhibitors (ACE-IS) and diuretics (used as antihypertensive agents) on global and domain-specific cognitive decline were evaluated in 326 non-demented community-dwelling participants over the age of 70 years in the Women's health and aging study II. Time-dependent Cox proportional hazards regression analysis was used for evaluating the association between parameters."

"The use of ACE-I for more than 3 years was associated with reduced incidence of impairment on Mini-mental state examination (MMSE), Trail making Test-Part A and Part B (TMT, Parts A and B), Hopkins Verbal learning Test-immediate recall (HVLT-I), and Hopkins Verbal learning Test-Delayed recall (HVLT-D). The use of diuretics for more than 3 years was associated with reduced incidence of impairment on MMSE, TMT, parts a and B, HVLT-I, and (HVLT-D). The presence of vascular disease did not make any difference to these effects," wrote S. Yasar and colleagues (see also Angiotensins).

The researchers concluded: "Therefore, the use of ACE-Is or diuretics was associated with reduced incidence of impairment of both global and domain-specific cognition in elderly women, and may help delay progression to dementia."

Yasar and colleagues published the results ...