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University of Paris reports research in Alzheimer disease.
In this recent study, researchers in Paris, France conducted a study "To prospectively evaluate the accuracy of automated hippocampal volumetry to help distinguish between patients with Alzheimer disease ( AD), patients with mild cognitive impairment (MCI), and elderly controls, by using established criteria for patients with AD and MCI as the reference standard. The regional ethics committee approved the study and written informed consent was obtained from all participants."
"The study included 25 patients with AD (11 men, 14 women; mean age +/- standard deviation [SD], 73 years +/- 6; Mini-Mental State Examination (MMSE) score, 24.4 +/- 2.7), 24 patients with amnestic MCI (10 men, 14 women; mean age +/- SD, 74 years +/- 8; MMSE score, 27.2 +/- 1.4) and 25 elderly healthy controls (13 men, 12 women; mean age +/- SD, 64 years +/- 8). For each participant, the hippocampi were automatically segmented on three-dimensional T1-weighted magnetic resonance (MR) images with high spatial resolution. Segmentation was performed by using recently developed software that allows fast segmentation with minimal user input. Group differences in hippocampal volume were assessed by using Student t tests. To obtain robust estimates of P values, the correct classification rate, sensitivity, and specificity, bootstrap methods were used. Significant hippocampal volume reductions were detected in all groups of patients (-32% in AD patients vs controls, P
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