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One of the great difficulties facing people with AIDS is the enormous number of antimicrobial drugs they have to take every day.
The toxicity, expense, and inconvenience of this shotgun approach to preventing life-threatening opportunistic infections (OIs) could be reduced by more rational prophylaxis strategies, an infectious disease expert suggests.
William G. Powderly of Washington University, St. Louis, Missouri, urged researchers to focus on why some patients develop specific OIs and some do not. Data from such studies could be used to individually tailor OI prophylaxis strategies and perhaps improve not only the length, but also the quality of patients' …