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The rapid appearance of drug-resistant HIV-1 virus in serum of patients treated with lamivudine is followed by an increase in viral RNA load, according to a multicenter report.
The appearance of in vivo HIV-1 with reduced sensitivity to zidovudine, ddI, ddC, and the nonnucleoside reverse transcriptase (RT) inhibitors (NNRTIs) has been well documented. In vitro selection experiments with the novel RT inhibitor (-)-enantiomeric 2'-deoxy-3'-thiacytidine (lamivudine) have shown that viruses can be selected with a highly resistant phenotype. The IC of these variants is 500- to 1000-fold greater than that of wild type virus.
"This resistance to lamivudine is caused …