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IL-10 contributes to AIDS-related B-cell lymphoma.(interleukin-10)

AIDS Weekly

HIV induced interleukin-10 (IL-10) production plays a central role in the pathogenesis of AIDS lymphoma, a recent study concluded.

Previous research has suggested that the pathogenesis of AIDS-related lymphoma is related to the induction of B-cell proliferation followed by transforming genetic events. As IL-10 stimulates the growth and differentiation of B lymphocytes, it may contribute to the development of B-cell lymphoma.

Rizwan Masood et al. evaluated whether IL-10 expression was associated with autocrine stimulation of AIDS-related lymphoma cells ("Interleukin-10 is an Autocrine Growth Factor for Acquired Immunodeficiency Syndrome-Related B-Cell Lymphoma," …

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