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Researchers evaluated the effects of Interleukin-1 (IL-1) and Interleukin-1 receptor antagonist (IL-1ra) on AIDS-Kaposi's sarcoma (AIDS-KS).
Previous research has suggested that HIV-1 may induce KS directly through viral protein(s) or indirectly through regulation of cytokine such as IL-1 and IL-6. The possibility exists that HIV can induce cytokine production (IL-1), which can then act as a paracrine factor for AIDS-KS cells.
Stan Louie et al. have shown that AIDS-KS spindle cells express IL-1(beta) and that IL-1ra inhibits KS spindle cell growth ("Effects of Interleukin-1 and Interleukin-1 Receptor Antagonist in AIDS-Kaposi's Sarcoma," Journal of Acquired …