Adoptive cell-mediated immunity to the purified protein derivative (PPD) of a mycobacterium tuberculosis in severe combined immunodeficient (SCID) mice.(Research Report)

According to an abstract submitted by authors to the Keystone Symposium Control and Manipulation of the Immune Response, held March 16-22, 1995, in Taos, New Mexico, "The immunocompetent C.B-17+/+ (C.B-17) inbred mouse strain possesses normal levels of T and B lymphocytes and develops normal protective immune responses. In contrast, severe combined immunodeficient C.B-17scid/scid (SCID) inbred mice lack T and B lymphocytes and do not develop specific immune responses. Intradermal challenge with the purified protein derivative of M. tuberculosis (PPD) produced a vigorous cell-mediated delayed-type hypersensitivity (DTH) response in C.B-17 mice immunized with complete Freund's …