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Clinical News: Glitazone heart failure risk warning.(Brief article)

Chemist & Druggist

| July 28, 2007 | COPYRIGHT 2003 CMP Information Ltd. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

Patients taking the diabetes drugs rosiglitazone and pioglitazone may be twice as likely to develop heart failure than patients who take alternative treatments, a large meta-analysis has suggested.

The authors said that the treatments should be re-evaluated by Nice, which currently recommends both drugs. Rosiglitazone (Avandia) and pioglitazone (Actos) were used by 1.5 million people in the UK last year.

Information leaflets provided with the drugs say that pioglitazone and rosiglitazone should not be taken by patients known to have heart failure, but the new results suggest that the drugs can provoke problems in patients with no history of the disease.…

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