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New drug profile: Maraviroc: it's different, it's strong, and it's almost here.(Drug overview)
What is it?
Maraviroc (or Celsentri) is an HIV medication, the first of its kind. Maraviroc doesn't block HIV directly; instead, maraviroc binds to a human protein known as CCR5. This is one of the proteins HIV uses to enter human T cells. By binding to CCR5, maraviroc keeps HIV from infecting T cells.
Who's it for?
Maraviroc, in combination with other HIV meds, is indicated for treatment-experienced adults infected with CCR5-tropic (attracted to something specified) HIV.
What does that mean?
In order for HIV to infect a T cell, the virus must first latch onto a receptor (nerve ending), called CD4, on the cell's surface. Researchers have known for a long time that HIV needs a second receptor on the CD4 receptor to enter the T cell. The others receptors that it uses are CCR5 and CXCR4, with CCR5 being the most common. The new drug, maraviroc, has the ability to block HIV that uses CCR5, but not HIV that uses CXCR4. This is the first time that a treatment for HIV is targeting a function of the cells in the body, not the virus itself.
How do I know what kind of virus I have?
- Pfizer Receives Positive Opinion from CHMP for Celsentri(R) (maraviroc) for...
- Press release article from: Business Wire July 19, 2007 700+ words
...for Celsentri[R] (maraviroc), the first CCR5...only CCR5-tropic virus is detectable. The...England, since 1997, maraviroc works extracellularly...white blood cells, maraviroc prevents the virus from entering white...
- Pharmacology Update: Maraviroc Tablets (Selzentry™).(Drug...
- Magazine article from: Internal Medicine Alert September 29, 2007 700+ words
...or malignancy.1 Maraviroc is not effective...tropic or dual tropic viruses. It interacts with...CYP3A4. Comments Maraviroc joins enfuviritide...entry of HIV-1. Maraviroc antagonizes the...gp120. HIV-1 virus can be classified...2 Transmitted viruses are generally CCR5...
- Pfizer's Maraviroc, Novel Medicine For HIV, Significantly Reduces Viral Load,...
- Press release article from: PR Newswire March 1, 2007 700+ words
...experimental medicine, maraviroc, which tackles HIV...many patients receiving maraviroc with an optimized background...achieved undetectable virus in the blood than if...scientists in 1997, maraviroc is an oral medicine...cells, it prevents the virus from entering uninfected...
- Pfizer's maraviroc, novel medicine for HIV, significantly reduces viral load,...
- News wire article from: Chemical Business Newsbase March 1, 2007 700+ words
...its experimental medicine, maraviroc, which tackles HIV in an entirely...as many patients receiving maraviroc with an optimized background regimen achieved undetectable virus in the blood than if an optimized...European regulatory review of maraviroc as a treatment for patients...
- Monogram Provides Update on Trofile(TM) Assay - Pfizer Reports Significant...
- Press release article from: PR Newswire March 1, 2007 700+ words
...many patients receiving maraviroc with an optimized background...achieved undetectable virus in the blood than if...the group receiving maraviroc plus an optimized regimen...duration of exposure. Maraviroc is designed to work...antagonists block the virus from gaining access...
- Monogram provides update on Trofile assay - Pfizer reports significant...
- News wire article from: Chemical Business Newsbase March 1, 2007 700+ words
...its experimental medicine, maraviroc, which tackles HIV in an entirely...as many patients receiving maraviroc with an optimized background regimen achieved undetectable virus in the blood than if an optimized...European regulatory review of maraviroc as a treatment for patients...
- Pfizer says maraviroc 'significantly' reduces viral load in combination therapy.
- News wire article from: Europe Intelligence Wire March 2, 2007 700+ words
...said its experimental medicine maraviroc, which treats HIV, "significantly...double the patients receiving maraviroc plus an optimized background regimen, showed undetectable virus in the blood, compared to...European regulatory review of maraviroc as a treatment for patients...
- Pfizer Receives Approvable Letter From FDA For Maraviroc.
- Press release article from: Business Wire June 20, 2007 700+ words
...approvable letter for maraviroc, which is under review...is committed to making maraviroc available to the thousands...patients with HIV whose virus has become resistant to...receiving treatment with maraviroc through clinical trials...
- US FDA approves Pfizer's maraviroc.(Food and Drug Administration)(Brief article)
- Newspaper article from: Pharma Marketletter August 13, 2007 700+ words
World drug giant Pfizer's CCR5 antagonist maraviroc has been approved as a treatment for patients...HIV-1 in the USA. Rather than fighting the virus inside white blood cells, maraviroc prevents it from entering uninfected cells by...
- Phase 1/2a Study Results Indicate Maraviroc Well-Tolerated In Doses Up To 300...
- Press release article from: PR Newswire July 26, 2005 700+ words
...CCR5-antagonists," maraviroc blocks HIV from entering...blood cells, where the virus replicates, takes over...studies in 63 patients, maraviroc reduced HIV viral load...logarithmic measures of virus per milliliter of blood...data also showed that maraviroc's efficacy did not...
Source: HighBeam Research, New drug profile: Maraviroc: it's different, it's strong, and it's...