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Perlegen seeking genes responsible for Actos, Avandia side effects.

Pharma Marketletter

| June 25, 2007 | COPYRIGHT 2009 Marketletter Publications Ltd. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

California, USA-based Perlegen Sciences says that it has completed the collection of more than 3,000 DNA samples from diabetic patients treated with Actos (pioglitazone) and Avandia (rosiglitazone) in order to analyze the genetic variability associated with adverse events due to treatment with this class of medications.

An estimated 200 million people worldwide have type 2 diabetes, including close to 20 million in the USA. In the late 1990s, insulin sensitizing thiazolidinediones (TZDs, the class of drugs to which Actos and Avandia belong) were approved in the USA for the treatment of type 2 diabetes. The main side effect from TZDs is fluid retention, leading to…

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