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Autoantibodies to the alpha/beta T-cell receptors in human immunodeficiency virus infection: dysregulation and mimicry. (reprinted from the Proceedings of the National Academy of Sciences of the United States of America, November 8, 1994) (Periodical Report) (Abstract)
According to the authors' abstract of an article published in Proceedings of the National Academy of Sciences of the United States of America, "Autoimmune reactivity is a consequence of infection with human immunodeficiency virus (HIV). We studied serological cross-reactions of purified pooled IgG from sera of HIV-infected individuals by using nested sets of synthetic overlapping peptides duplicating the covalent structures of T-cell receptors (TCRs) and immunoglobulin light chains and report that two professes of autoantibody production occur. (i) IgG autoantibodies to putative regulatory variable domain CDR1 and FR3 epitopes (where CDR is complementarity-determining region …
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- HIV infection leads to elevated IGG autoantibodies to TCR. (immunoglobulin G,...
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Newspaper article from: AIDS Weekly
January 9, 1995
700+ words
