Specific inhibition of viral protein synthesis in HIV-infected cells in response to interferon treatment. (Research Report)

According to an abstract submitted by the authors to the Annual Meeting of the International Society for Interferon and Cytokine Research, held October 2-7, 1994, in Budapest, Hungary, "The mechanism of action of different types of interferons (IFN-a, -b and -gamma) against HIV-1 infection was investigated in chronically infected monocytoid U937 cells, and during an acute infection of the T-lymphoblastoid CEM cells. Two chronically infected U937 cell populations, obtained independently (referred to as type A and B cells), were analyzed for their response to IFNs. In type A cells, IFNs mainly inhibited virus particle release whereas in type B cells, the anti-HIV effect of IFNs …