Vaccine-induced protection against SIV is demonstrated. (simian immunodeficiency virus)

Vaccine-induced protection against challenge with SIV-infected cells of the same host species was demonstrated in a study involving rhesus macaques, researchers reported.

SIV and HIV-2 macaque models have been used extensively in studies to evaluate strategies to develop candidate vaccines against HIV infection in humans.

Petra de Vries, National Institute of Public Health and Environmental Protection, Bilthoven, Netherlands, and colleagues challenged immunized monkeys with cell-free or cell-associated homologous SIV preparations to evaluate the potential of the two approaches for the development of candidate vaccines against infections with lentiviruses …