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Using gene therapy to reduce the adrenal gland's output of fight or flight hormones could protect against heart failure, US research suggests.
The findings offer a strategy to treat heart failure and help to explain why sympatholytic agents have been unsuccessful in protecting against heart failure.
Currently, beta-blockers are used to inhibit the beta-adrenergic receptors on the heart, blocking the catecholamines that force the heart to work too hard, leading to heart failure.
However, beta-blockers do not reduce the levels of catecholamine produced by the adrenal gland.
By targeting the adrenal gland, the researchers found that they …