Cognitive difficulties following simvastatin.(Case Reports)(Brief article)

Patient: Male, 64 y/o

Medications: simvastatin (Zocor)

Comments: Within one week of starting simvastatin 40 mg/day, a 64-year-old man began to experience cognitive difficulties. Although the patient had experienced difficulties with remembering names and word-finding before beginning statin therapy, new-onset problems developed involving short-term memory, long-term memory, and item-misplacement. Other evidence of the patient's cognitive difficulties included a decline of 3 points on the Mini-Mental State Examination (MMSE) 2 weeks after starting statin therapy, as well as other declines in scales of Activities of Daily Living, and Instrumental Activities of …