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Patient: Male, 64 y/o
Medications: simvastatin (Zocor)
Comments: Within one week of starting simvastatin 40 mg/day, a 64-year-old man began to experience cognitive difficulties. Although the patient had experienced difficulties with remembering names and word-finding before beginning statin therapy, new-onset problems developed involving short-term memory, long-term memory, and item-misplacement. Other evidence of the patient's cognitive difficulties included a decline of 3 points on the Mini-Mental State Examination (MMSE) 2 weeks after starting statin therapy, as well as other declines in scales of Activities of Daily Living, and Instrumental Activities of …