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IL-12 may prevent M. avium infection in HIV-positive patients. (interleukin-12; Mycobacterium avium)
Interleukin-12 may be useful as an enhancer of cell-mediated immunity against Mycobacterium avium infections in AIDS patients, according to a report from Boston's Harvard Medical School.
Researcher Gale W. Newman and colleagues conducted in vitro examination of IL-12 to determine if it enhanced proliferative responses to M. avium of peripheral blood mononuclear cells (PBMC) from HIV-positive donors with CD4 cell counts ("IL-12 Enhances Antigen-Specific Proliferation of PBMC From HIV-Positive and Negative Donors in Response to Mycobacterium avium," AIDS;8(10):1413-1419).
PBMC proliferative responses to virulent and avirulent serovars of M. avium in the …
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