Animal model for testing env-based HIV-1 vaccines.

X International Conference on AIDS

Two separate research laboratories have successfully infected monkeys with chimeric simian immunodeficiency virus (SIV) viruses genetically engineered to express HIV-1 proteins.

Both chimeric HIV-1/SIV constructs are expected to be useful in animal tests of candidate HIV vaccines containing the viral envelope glycoprotein, the U.S. and Japanese research teams reported at the X International Conference on AIDS, held August 7-12, 1994, in Yokohama, Japan.

At the University of California, San Francisco, noted AIDS researchers Cecilia Cheng-Mayer, Jay Levy and P.A. Luciw removed the tat, rev and envgp160 genes from …