IL-10 inhibits HIV-1 replication and is induced by Tat. (interleukin-10)(adapted from Biochemical and Biophysical Research Communications, July 15, 1994) (Periodical Report) (Abstract)

SOURCE: Biochemical and Biophysical Research Communications, July 15, 1994;202(1):374-383.

According to the authors' abstract of an article published in Biochemical and Biophysical

Research Communications, "Interleukin 10 (IL-10) is produced by T(H)2 lymphocytes and regulates both lymphoid and myeloid cells. In the present study we demonstrate that IL-10 is expressed and produced spontaneously in the peripheral blood mononuclear cells (PBMCs) of all HIV-1-infected individuals tested, 3 of 19 cases of HIV-negative lymphoma and none of five healthy controls. IL-10 mRNA was detectable in both monocytes/macrophages and T lymphocytes isolated from PBMCs of …