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Rx for heart failure-related apnea.(acetazolamide for central sleep apnea)(Brief article)
A 6-day course of acetazolamide appeared to improve sleep-disordered breathing in a study of 12 men with heart failure-related central sleep apnea.
In central sleep apnea (CSA), respiration temporarily ceases because of a decline in partial pressure of carbon dioxide (PC[O.sub.2]) below the apneic threshold. However, in a randomized, double-blind study by Dr. Shahrokh Javaheri and his associates, the diuretic and respiratory stimulant acetazolamide seemed to reduce the likelihood of PC[O.sub.2] crossing the apneic threshold by inducing a state of metabolic acidosis. Dr. Javaheri of the University of Cincinnati and associates evaluated acetazolamide in 12 men with stable heart failure with left ventricular systolic dysfunction and CSA (Am. J. Respir. Crit. Care Med. 2006;173:234-7).
For 6 nights, patients received either placebo or a single dose (3.5 mg/kg) of acetazolamide and 30 mEq of potassium chloride (to offset the urinary potassium loss ...
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- News wire article from: Ascribe Higher Education News Service November 9, 2005 700+ words
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...Percutaneous coronary intervention can improve sleep apnea. "Central sleep apnea is often recognized in patients with heart failure...reported "a chronic heart failure patient with central sleep apnea whose nocturnal desaturation was improved by...
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...approved for the treatment of central sleep apnea, mixed sleep apnea, and periodic...obstructive sleep apnea, 12% with central sleep apnea, and 21% with mixed obstructive and central sleep apnea. One-third of the patients...