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Recreation of 1918 flu offers insight into dangers of avian flu.

The Philadelphia Inquirer (Philadelphia, PA)

| October 05, 2005 | Uhlman, Marian | COPYRIGHT 2007 The Philadelphia Inquirer. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

Byline: Marian Uhlman

PHILADELPHIA _ Using new genetic information from the deadly 1918 Spanish influenza, scientists say the lethal avian flu plaguing Southeast Asia could evolve in a similar way to become a global human menace.

Up to now, many people thought the bird virus would need to mix with a human virus before it could become a pandemic strain.

But now, scientists believe it also could undergo its own genetic changes and morph into a version that would spread easily among people, according to an article in this week's issue of the journal Nature.

The present flu strain, which has infected more than 100 people and killed at least 60, mostly in Vietnam, already has experienced several changes that mimic those in the 1918 virus, according to Dr. Jeffery Taubenberger, the study's lead author.

"It makes the situation scarier," said Taubenberger, chief of the Molecular Pathology Department at…

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