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Thiol suppression of human immunodeficiency virus type-1 replication in primary cord blood monocyte-derived macrophages in vitro. (Periodical Report)
SOURCE: Journal of Clinical Investigation, February 1993;91(2):495-498.
Glutathione (GSH) and N-acetylcysteine (NAC) suppress HIV*1 replication in monocyte-derived macrophages, an in vitro study shows.
Glutathione (GSH) is a cysteine-containing tripeptide (L-gamma-glutamyl-L-cysteinyl glycine) found in millimolar concentrations within eukaryotic cells. It has a number of important cellular functions, including the transport of amino acids, enhancement of enzyme -dependent reactions, and maintenance of protein sulphydryl redox status. Perhaps most important among these functions is its action as the principal intracellular defense against oxidation by …
