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Autologous antibody response against the principal neutralizing domain of human immunodeficiency virus type-1 isolated from infected humans. (Periodical Report)
SOURCE: Journal of Virology, March 1993;67(3):1612-1619.
HIV-infected individuals at all stages of infection have antibodies that recognize the so-called principal neutralizing domain of HIV*1, a Danish study suggests.
K. Holmback of the State Serum Institute, Copenhagen, Denmark, and colleagues note that neutralizing antibodies in HIV*1 infection are directed primarily against the third hypervariable domain (the V3 loop) of the viral gp120 envelope glycoprotein. For this reason the V3 loop has been designated the principal neutralizing domain (PND) of HIV*1.
In the current study, Holmback et al. explored the frequency and significance of …
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