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Cancer Gene MYC Shown to Activate Gene Involved in Metastasis; Study Points to Importance of Pathway in Cancer Progression.

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| September 12, 2005 | COPYRIGHT 2009 AScribe. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

Byline: The Wistar Institute

PHILADELPHIA, Sept. 12 (AScribe Newswire) -- The cancer gene MYC is among the most commonly overexpressed oncogenes in human cancers. Most human cancers demonstrate high levels of MYC or its biological partners, including those of the breast, ovaries, lung, prostate, and skin, as well as leukemias and lymphomas. MYC is a regulator of other genes - a transcription factor - and scientists have been working for more than two decades to identify its target genes in order to understand how MYC causes so many cancers.

Now, scientists at the Wistar Institute have shown that MYC activates a gene called MTA1, which has been demonstrated by…

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