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hu-PBL-SCID mice can be protected from HIV-1 infection by passive transfer of monoclonal antibody to the principal neutralizing determinant of envelope gp120. (Periodical Report)

AIDS Weekly

Immunodeficient (SCID) mice transplanted with normal human peripheral blood leukocytes (hu-PBL) and then injected with either a murine monoclonal HIV-neutralizing antibody (BAT123) or a mouse/human chimeric form of the antibody (CGP 47 439) remained uninfected after receiving 10 mouse-infectious doses of HIV-1.

BAT123 is a mouse monoclonal antibody specific for the principal neutralizing determinant in the so-called V3 loop of HIV-1IIIB. CGP 47 439 is a mouse-human chimeric antibody incorporating BAT123.

In the present study, J.T. Safrit of the Aaron Diamond AIDS Research Center and colleagues tested whether passive transfer of these antibodies to …

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