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Flucloxacillin treatment is very rarely associated with an increased risk of hepatic disorders, namely, hepatitis and cholestatic jaundice. In some patients, almost always those with serious underlying disease, these adverse reactions have been fatal.
The United Kingdom Committee on Safety of Medicines (CSM) has previously advised that:
* The onset of hepatic reactions may be delayed for several weeks (up to 2 months) after treatment with flucloxacillin has stopped.
* These reactions are related neither to the dose nor to the route of administration of flucloxacillin.
* Risk factors include treatment for more than …