Simvastatin trial suggests statins may treat PCOS.(Gynecology)(polycystic ovarian syndrome)

LOS ANGELES -- Simvastatin lowered testosterone levels by 41%, normalized gonadotropin levels, and reduced cardiovascular risk factors in a small, randomized, controlled trial, suggesting that statins may be a potential treatment for polycystic ovarian syndrome.

"Statins would improve the metabolic profile in those patients in terms of lipid levels as well as improve the hormonal problems," study investigator Antoni J. Duleba, M.D., said during the annual meeting of the Society for Gynecologic Investigation.

The study is the first to demonstrate these benefits in women with polycystic ovarian syndrome (PCOS). Dyslipidemia is common with PCOS, but statins are almost never used in PCOS, because the patients are typically young women trying to get pregnant or are at risk of getting pregnant. Statins are contraindicated in pregnancy, said Dr. Duleba of Yale University, New Haven.

The study eliminated pregnancy as a consideration by placing all 48 study participants on oral contraceptive pills (OCP) containing 20 mcg of ethinyl estradiol and 150 mcg of desogestrel. One 24-patient cohort was treated with 20 mg of simvastatin daily, along with OCP; the other 24 patients received only OCP.

Investigators from Yale and Poznan University of Medical Sciences in Poland are conducting the ongoing trial in that country. The women are about 23 years old on average. None received any hormonal treatment or OCPs for at least 3 months before enrollment. Organon Inc. supplied the OCP Marvelon, and Polfa, a Polish pharmaceutical company, provided simvastatin.

A comparison of hormonal levels at baseline and 12 weeks showed total testosterone fell significantly--an average of 34.6 ng/dL (41%) in the OCP/simvastatin group. By contrast, in the OCP-alone group, levels fell by only 10.9 ng/dL (14%).

Average dehydroepiandrosterone sulfate (DHEA-S) fell 26% in the OCP/simvastatin patients and 28% in the OCP-alone group. Luteinizing hormone (LH), however, was reduced 43% in the OCP/simvastatin group vs. 9% in the OCP-alone cohort.