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Study identifies novel breast cancer prognostic markers.(Gynecology)
ATLANTA -- New data suggest that the Notch signaling genes--Notch1 and Jagged1--are potential novel prognostic markers for breast cancer, Michael Reedijk, M.D., FACS, reported at a symposium sponsored by the Society of Surgical Oncology.
"Patients expressing high levels of Jagged1 or Notch1 demonstrated significantly poorer overall survival than patients expressing low levels," said Dr. Reedijk of University Health Network, Princess Margaret Hospital in Toronto.
Abnormal Notch signaling has been observed in a number of malignancies, but this is the first report of direct evidence linking high-level Notch1 and Jagged1 expression with poorer outcomes in women with breast cancer.
The data also suggest a mechanism by which Notch is activated in aggressive breast cancer that may be targeted with drugs currently under development for Alzheimer's disease, Dr. Reedijk said.
Dr. Reedijk and colleagues at Toronto's Hospital for Sick Children and the University Health Network analyzed tumor samples from 184 breast cancers using in situ hybridization. One-third of the cancers were node-positive, one-third were node-negative, and one-third had metastasized at presentation. Notch2 was expressed at high levels in most tumors.
In contrast, high levels of Notch1, Jagged1, and Notch3 were found ...
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Source: HighBeam Research, Study identifies novel breast cancer prognostic markers.(Gynecology)