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Tamoxifen alone discouraged as adjuvant Tx.(Gynecology)
HOLLYWOOD, FLA. -- An aromatase inhibitor, either alone or after tamoxifen therapy, is better than tamoxifen alone for the long-term prevention of breast cancer in postmenopausal women with invasive breast cancer, according to updated treatment guidelines from the National Comprehensive Cancer Network.
Several recent clinical trials have shown that adjuvant endocrine therapy with the aromatase inhibitors anastrozole (Arimidex), letrozole (Femara), and exemestane (Aromasin) can significantly improve disease-free survival in postmenopausal women, compared with tamoxifen as a single agent.
Consequently, "tamoxifen alone [in this patient population] has fallen off the radar screen," said Robert Carlson, M.D., chair of the NCCN panel that revised the guidelines, which were last updated in 2004. The network's 19 member institutions are designated as comprehensive cancer centers by the National Cancer Institute.
The updated guidelines recommend that women who are postmenopausal when they begin adjuvant therapy receive one of the following treatment regimens:
* Anastrozole for 5 years.
* Tamoxifen for 2-3 years, followed by exemestane or anastrozole to complete 5 years of therapy.
* Tamoxifen for 4.5-6 years, followed by letrozole for 5 years.
- Tamoxifen and the uterus: women given this drug need careful assessment....
- Magazine article from: British Medical Journal Neven, P. Muylder, X. de Belle, Y. van Campo, R. Vanderick, G. November 19, 1994 700+ words
...findings in patients taking tamoxifen have been mostly benign...possibly associated with tamoxifen--estimated at a maximum of 20 per 10 000 women per year.[4] This discrepancy...hazards associated with tamoxifen ought to be preventable...
- Tamoxifen (Systemic).
- USP DI-Volume II, Advice for the Patient: Drug Information in Lay Language January 1, 1997 700+ words
Some commonly used brand names are: In the U.S. -- Nolvadex In Canada -- Alpha-Tamoxifen Med Tamoxifen Nolvadex Nolvadex-D Novo-Tamoxifen Tamofen Tamone Tamoplex Description Tamoxifen (ta-MOX-i-fen) is a medicine that blocks...
- Tamoxifen benefit lasts 10 years, new data show: the relative risk of breast...
- Magazine article from: Clinical Psychiatry News Jancin, Bruce February 1, 2007 700+ words
...A new 10-year follow-up...clinical trial of tamoxifen for breast cancer...the standard 5 years of therapy...based on just 5 years of data...presented a 10-year update from...randomized to 5 years of daily tamoxifen or placebo...
- Tamoxifen Prophylaxis Okay in High-Risk Cases.(Brief Article)
- Magazine article from: Family Practice News BOSCHERT, SHERRY June 15, 1999 700+ words
...that the risks of tamoxifen might outweigh the...group said that tamoxifen may be offered to women who are aged 35 years and older and have...the following 5 years. That recommendation...trial reported last year by the National...Trial (P-1), tamoxifen nearly halved the...
- Tamoxifen benefit persists 10 years, new data show: risk-benefit ratio rises...
- Magazine article from: Internal Medicine News Jancin, Bruce January 15, 2007 700+ words
...A new 10-year follow-up...clinical trial of tamoxifen for breast cancer...the standard 5 years of therapy...based on just 5 years of data...presented a 10-year update from...randomized to 5 years of daily tamoxifen or placebo...
- Tamoxifen and breast cancer incidence among women with inherited mutations in...
- Newspaper article from: Clinical Oncology Alert January 1, 2002 700+ words
...P-1), revealed that tamoxifen conferred a protective effect...selected for age > 60 years, age < 60 years with a 5-year predicted risk for breast...ingested placebo or 20 mg tamoxifen daily for 5 years, a risk reduction of 49...
- Tamoxifen 'breakthrough' a bitter pill to swallow.
- Magazine article from: Herizons Mitchell, Penni June 22, 1998 700+ words
...Yet the five year survival rate...study is that tamoxifen's ability to...been used for 20 years to reduce recurrence...off at the 5 year mark is curious...drawbacks of tamoxifen is that reports...within about 5 years. In fact, tamoxifen...
- Tamoxifen for breast cancer chemoprevention: low uptake by high-risk women...
- Magazine article from: Annals of Family Medicine Taylor, Rebecca Taguchi, Kenneth May 1, 2005 700+ words
...choosing to take tamoxifen for chemoprophylaxis...lifetime and 5-year risk of developing...cancer in the next 5 years, the same as that...Women older than 80 years were excluded. Informed...her estimated 5-year and lifetime risk...to discuss taking tamoxifen for breast cancer...
- Tamoxifen (Systemic).(Antineoplastic agent overview)(Drug overview)
- USP DI-Volume II, Advice for the Patient: Drug Information in Lay Language August 1, 2006 700+ words
...D Novo-Tamoxifen PMS-Tamoxifen Tamofen Tamone Antineoplastic Description Tamoxifen ( ta-MOX-i-fen) is...determined by your doctor. Tamoxifen also may be used to reduce...breast cancer are at least 35 years of age and have a combination...
- Tamoxifen-resistant tumors alter their traits, become receptive to new...
- Newspaper article from: Cancer Weekly January 21, 2003 700+ words
...that stop responding to the drug tamoxifen actually change their cellular...of mice that are resistant to tamoxifen's tumor-shrinking effects...model of a woman who has been on tamoxifen for 2 years and whose cancer has recurred...
Source: HighBeam Research, Tamoxifen alone discouraged as adjuvant Tx.(Gynecology)