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Fibromyalgia pain responds to dopamine-3 receptor agonist.(Musculoskeletal Disorders)

Family Practice News

| February 15, 2005 | Walsh, Nancy | COPYRIGHT 2009 International Medical News Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

SAN ANTONIO -- The dopamine-3 receptor agonist pramipexole significantly improved pain, function, and fatigue in patients with severe, longstanding fibromyalgia, Andrew J. Holman, M.D., said in a late-breaking abstract session at the annual meeting of the American College of Rheumatology.

In a double blind, randomized, placebo controlled clinical trial that included 60 patients, pain as measured on a 10-point visual analog scale (VAS) improved by 36%, from a mean score of 7.0 at baseline to 4.5 after 14 weeks of treatment with pramipexole.

By contrast, patients receiving placebo experienced only a 9% decrease in pain, from 7.54 to 6.82. At baseline, all…

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