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Africa, India test sites for anti-HIV microbicide: cellulose sulfate tested in high-risk women.
Phase III effectiveness clinical trials have begun for the potential anti-HIV microbicide cellulose sulfate (Ushercell), formerly called C31G, which already has demonstrated safety when used by women. (1-4)
If the trials go well, the product could be ready for approval by the Food and Drug Administration (FDA) by 2010.
Cellulose sulfate is being evaluated in two studies, each enrolling 2,400 women considered at high-risk of HIV infection, explains Henry L. Gabelnick, PhD, director of the Contraceptive Research and Development Programme (CONRAD) in Arlington, VA.
"In our studies, we're looking at women who are at high risk from having multiple sex partners per week and multiple acts of intercourse," he says.
Preliminary data show the microbicide is as effective as a spermicide as anything else that's available, and it's worked quite well in vitro as an anti-HIV microbicide, Gabelnick…
- Research halted on cellulose sulfate microbicide - What's next in research?
- Magazine article from: Contraceptive Technology Update April 1, 2007 700+ words
...priority, says Henry Gabelnick, PhD, CONRAD executive...from the trials of cellulose sulfate and will use that...microbicide," said Gabelnick in a statement following...participating women were given cellulose sulfate, and half were given...
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- Magazine article from: Family Practice News Lowry, Fran July 1, 2006 700+ words
WASHINGTON -- Cellulose sulfate, a new vaginal gel that is...typical" and "perfect" use of cellulose sulfate was 13.9 and 3.9, respectively...Arlington, and associates. Cellulose sulfate is an antimicrobial that stimulates...
- Cellulose sulfate microbicide trial stopped.(ROUND UP: HIV/AIDS)(Clinical...
- Magazine article from: Reproductive Health Matters May 1, 2007 700+ words
...study of the candidate microbicide cellulose sulfate to prevent HIV transmission in women...protection against HIV infection. Cellulose sulfate was one of four compounds being evaluated...is as yet no explanation as to why cellulose sulfate was associated with a higher risk...
- Cellulose sulfate microbicide trial halted.
- News wire article from: UPI NewsTrack January 31, 2007 700+ words
...halted a Phase III clinical trial of cellulose sulfate -- a topical microbicide gel being...trial when preliminary data indicated cellulose sulfate could lead to an increased risk of...Uganda, and India. Another Phase III cellulose sulfate trial in Nigeria was halted by Family...
- New vaginal gel safe and effective for contraception, HIV prevention.(Women's...
- Magazine article from: Internal Medicine News Lowry, Fran August 15, 2006 700+ words
WASHINGTON -- Cellulose sulfate, a new vaginal gel being developed...typical" and "perfect" use of cellulose sulfate was 13.9 and 3.9, respectively...Arlington, and associates. Cellulose sulfate is an antimicrobial that stimulates...
- U.S. is number one in arms sales.(By Pamina Firchow and Tamar Gabelnick)
- Newspaper article from: Knight Ridder/Tribune News Service Firchow, Pamina Gabelnick, Tamar August 29, 2000 700+ words
...misguided policy. X XX ABOUT THE WRITERS Pamina Firchow and Tamar Gabelnick track U.S. arms sales for the Federation of American Scientists...Information Services. (c) 2000, Pamina Firchow and Tamar Gabelnick Distributed by Knight Ridder/Tribune Information Services...
- EVMS receives $24 million grant.
- Newspaper article from: The Virginian-Pilot (Norfolk, Virginia) (via Knight-Ridder/Tribune Business News) May 4, 2005 700+ words
...Administration, said Henry L. Gabelnick, CONRAD's director. The...If the study goes well, Gabelnick and others think, it could...Ushercell, also known as cellulose sulfate, is owned and manufactured...that's a huge feat, Gabelnick said. "People don't use...
- CONRAD Announces Results of Phase II Clinical Trial for Ushercell.
- Press release article from: PR Newswire January 26, 2006 700+ words
...effectiveness. Ushercell is a vaginal gel containing 6% cellulose sulfate, which is being developed to prevent pregnancy and sexually...confident in our development plan for Ushercell," said Henry Gabelnick, Ph.D., executive director of CONRAD. The primary...
- HIV-blocking contraceptive gel in phase II trials.(News)
- Magazine article from: OB GYN News Lowry, Fran July 1, 2006 700+ words
WASHINGTON -- Cellulose sulfate, a new vaginal gel that is...typical" and "perfect" use of cellulose sulfate was 13.9% and 3.9...Arlington, and her associates. Cellulose sulfate is an antimicrobial that stimulates...
- Anti-HIV specialists disappointed over calling off human trial.
- News wire article from: PTI - The Press Trust of India Ltd. February 4, 2007 700+ words
...stopped a Phase III clinical trial of cellulose sulfate -- a topical microbicide gel being...preliminary results indicated that cellulose sulfate could lead to an increased risk of...FHI) has halted a second Phase III cellulose sulfate trial in Nigeria. Indian Council...
Source: HighBeam Research, Africa, India test sites for anti-HIV microbicide: cellulose sulfate...
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