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Stable expression of transdominant rev protein in human T cells inhibits human immunodeficiency virus replication. (Periodical Report)
SOURCE: Journal of Experimental Medicine, October 1992;176(10):1197-1201.
Insertion of a mutant, transdominant HIV-1 rev gene into T cells suppresses HIV replication without affecting T-cell function, in vitro studies show.
These findings support the feasibility of a new gene therapy for AIDS, possibly by using altered CD4+ T cells or progenitor cells to reconstitute patients' immune systems.
Duke University researcher Michael H. Malim, University of Michigan researcher Gary J. Nabel and colleagues note that one of the first steps in HIV infection of T cells is the expression of the viral rev protein. This protein, encoded by a fully spliced …
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