AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.

Epithelial hypoxia-inducible factor-1 protects against experimental colitis.

Vaccine Weekly

| December 29, 2004 | COPYRIGHT 2004 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2004 DEC 29 - (NewsRx.com & NewsRx.net) -- Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis.

According to recent research from the United States, "Mucosal epithelial cells are uniquely equipped to maintain barrier function even under adverse conditions. Previous studies have implicated hypoxia in mucosal tissue damage resulting from both acute and chronic inflammation. Given the importance of the transcriptional regulator hypoxia-inducible factor-1 (HIF-1) for adaptive hypoxia responses, we hypothesized that HIF-1 may serve as a barrier-protective element during mucosal inflammation. Initial studies of hapten-based murine colitis revealed extensive mucosal hypoxia and concomitant HIF-1 activation during colitis."

"To study this in more detail, we generated two mouse lines with intestinal epithelium-targeted expression of either mutant Hif1a (inability to form HIF-1) or mutant von Hippel-Lindau gene (Vblb; constitutively active HIF-1)," said Jorn Karhausen at Brigham and Women's Hospital and collaborators in the U.S. "Studies of colitis in these mice revealed that decreased HIF-1 expression correlated with more severe clinical symptoms (mortality, weight loss, colon length), while increased HIF levels were protective in these parameters."

"Furthermore, colons with constitutive activation of HIF displayed increased ...

Related articles from newspapers, magazines, journals, and more
Epithelial hypoxia-inducible factor-1 protects against experimental colitis.
Newspaper article from: Biotech Week December 29, 2004 700+ words
...regulator hypoxia-inducible factor-1 (HIF-1) for...in the Journal of Clinical Investigation (Epithelial hypoxia-inducible factor-1 is protective...for the Journal of Clinical Investigation is: American Society...
Competitor Analysis: Hypoxia-Inducible Factor (HIF).
Press release article from: M2 Presswire April 29, 2009 700+ words
...Competitor Analysis: Hypoxia-Inducible Factor (HIF)(C)1994-2009 M2 COMMUNICATIONS...Competitor Analysis: Hypoxia-Inducible Factor (HIF)" report to their offering...Intelligence Report about Hypoxia-Inducible Factor (HIF) provides a competitor evaluation...
Hypoxia-inducible factor 1 regulates several factors to control angiogenesis.
Newspaper article from: Drug Week January 23, 2004 700+ words
...amp; NewsRx.net) -- Hypoxia-inducible factor 1 regulates several factors to control...for ischemic disorders. Hypoxia-inducible factor 1 (HIF-1) activates vascular endothelial...constitutively active form of hypoxia-inducible factor 1. Circ Res, 2003;93(11...
Hypoxia-inducible factor 1 alpha is expressed early in prostate malignancies.
Newspaper article from: Drug Week July 9, 2004 700+ words
...amp; NewsRx.net) -- Hypoxia-inducible factor 1 alpha is expressed early in prostate...from the United States, "hypoxia-inducible factor 1 (HIF-1) activates the transcription...Prevention (Up-regulation of hypoxia-inducible factor 1 alpha is an early event in prostate...
Hypoxia-inducible factor 1 facilitates a number of human pathologies.
Newspaper article from: Angiogenesis Weekly August 6, 2004 700+ words
...amp; NewsRx.net) -- Hypoxia-inducible factor 1 facilitates a number of human pathologies...radiotherapy and chemotherapy. Hypoxia-inducible factor 1 (HIF-1) is an essential component...their findings in EJSO (Hypoxia-inducible factor I (HIF-1) in cancer. EJSO, 2004...
The hypoxia-inducible factor-1 inhibitor PX-478 abates large tumor growth.
Newspaper article from: Biotech Week May 12, 2004 700+ words
...NewsRx.net) -- The hypoxia-inducible factor-1 inhibitor PX-478 abates large...the United States, "the hypoxia-inducible factor-1 (HIF-1) transcription factor...478, an inhibitor of hypoxia-inducible factor-1 alpha. Mol Cancer Ther, 2004...
Akt and hypoxia-inducible factor-1 activate tumor growth independently.
Newspaper article from: Cancer Weekly July 20, 2004 700+ words
...NewsRx.net) -- Akt and hypoxia-inducible factor-1 activate tumor growth independently...growth by activating the hypoxia-inducible factor-1 (HIF-1). However, the absence...Cancer Research (Akt and hypoxia-inducible factor-1 independently enhance tumor growth...
Hypoxia circumvents hypoxia-inducible factor to rouse VEGF activity.
Newspaper article from: Health & Medicine Week April 19, 2004 700+ words
...Hypoxia circumvents hypoxia-inducible factor to rouse VEGF activity. "The induction...tumor angiogenesis, and the hypoxia-inducible factor-1 (HIF-1) transcription factor...study in Cancer Research (Hypoxia-inducible factor-1-independent regulation of vascular...
Drugs that target hypoxia inducible factor-1 alpha curtail cancer.
Newspaper article from: Cancer Weekly July 20, 2004 700+ words
...net) -- Drugs that target hypoxia inducible factor-1 alpha curtail cancer. According...the United States, "the hypoxia inducible factor 1 (HIF-1) is a heterodimeric transcription...Molecular Cancer Therapeutics (Hypoxia inducible factor-1 alpha as a cancer drug target...
Research and Markets: Competitor Analysis: Hypoxia-Inducible Factor (HIF).
Press release article from: Business Wire April 29, 2009 700+ words
...Competitor Analysis: Hypoxia-Inducible Factor (HIF)" report to their offering...Intelligence Report about Hypoxia-Inducible Factor (HIF) provides a competitor evaluation...angiogenesis as of April 2009. Hypoxia-inducible factor 1 (HIF-1) is a key regulator of...
For more facts and information, see all results

Source: HighBeam Research, Epithelial hypoxia-inducible factor-1 protects against experimental...

©2009 Gale, a part of Cengage Learning. All rights reserved.
About us | FAQs | Contact us | Privacy policy | Terms and conditions
Other Gale sites: Encyclopedia.com | HighBeam Research | Acquire Content | Books & Authors | Goliath | MovieRetriever | Smart QandA