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Chemokines may be novel therapeutic targets in osteoarthritis.
2004 DEC 29 - (NewsRx.com & NewsRx.net) -- Chemokines and their downstream signaling may be novel therapeutic targets in osteoarthritis.
According to published research from Italy, "Besides the well-known activities of the prototypical inflammatory cytokines (IL-1beta, TNF-alpha), a role for chemokines and their receptors in cartilage degradation in osteoarthritis has recently been reported. Human chondrocytes can produce CC and CXC chemokines and express chemokine receptors for both chemokine subfamilies. Engagement of these receptors can induce the release of matrix degrading enzymes such as matrix metalloproteinases 1, 3, and 13, and N-acetyl-beta-D-glucosaminidase."
"Furthermore GROalpha, a CXC chemokine acting on CXCR2, can activate an apoptotic pathway in chondrocytes that leads to chondrocyte cell death," wrote R.M. Borzi and colleagues.
The researchers concluded: "These findings suggest that chemokines can act as an autocrine or paracrine loop on chondrocytes and can contribute to many ...
- University-related research parks.(Real Numbers)
- Magazine article from: Issues in Science and Technology Link, Albert N. September 22, 2003 700+ words
A university-related research park is a cluster of technology...the population of university-related research parks and factors associated...Characteristics of University-Related Research Parks Percentage of parks formally...
- MoU on energy related research and technology between Norway and the US.
- Press release article from: M2 Presswire May 24, 2004 700+ words
...PRESSWIRE-24 May 2004-Norwegian Government: MoU on energy related research and technology between Norway and the US(C)1994-2004...Amsterdam. The two countries share a common interest on energy related research and technology, which may be strengthened through focused...
- UKRAINE-DEFENSE-RELATED-RESEARCH.
- Newspaper article from: Ukraine News April 21, 2006 700+ words
UKRAINE-DEFENSE-RELATED-RESEARCH About 80 defense-related research, test projects to be carried out in Ukraine in 2006 Kyiv, April 21 (Interfax-AVN) - As many as 77 research, development and test projects in the sphere of national...
- Ways in which signal transduction-related research is conducted.(SNAPSHOT)
- Magazine article from: Bioscience Technology May 1, 2007 700+ words
Ways In Which Signal Transduction-Related Research Is Conducted In Vitro 75.3% In Cell Models 66.0% In Vivo 53.6% In Animal Models 48.5% In Silico 16.5% % Respondents Source: Current Dynamics In Signal Transduction-Related Research, 2007
- South Korea committed nanotechnology-related research projects and has a clear...
- Press release article from: M2 Presswire March 31, 2004 700+ words
...Research and Markets: South Korea committed nanotechnology-related research projects and has a clear focus on a number of 'Core Technologies...of Electronic Devices. There are many nanotechnology-related research projects in government, university, and industrial laboratories...
- Humayun chairs WB seminar on trade related research studies.
- News wire article from: PPI - Pakistan Press International February 20, 2004 700+ words
...Commerce Minister, Humayun Akhtar Khan on Friday chaired a seminar on Trade Related Research Studies conducted by the World Bank. A list of eleven trade-related research studies was referred by the Ministry of Commerce in May 2003, to the donor...
- NISSAN PLANS SAFETY-RELATED RESEARCH IN MASSACHUSETTS
- Press release article from: PR Newswire October 23, 1992 700+ words
NISSAN PLANS SAFETY-RELATED RESEARCH IN MASSACHUSETTS FARMINGTON HILLS, Mich., Oct. 23 /PRNewswire/ -- Nissan today announced it plans to open a research office...
- Launching of Trade related research reports today.
- News wire article from: PPI - Pakistan Press International July 23, 2005 700+ words
ISLAMABAD, July 23 (PPI): Action Aid will launch its four Trade related research reports hete today (Sunday) in a local hotel. Recently the organization has completed the researches on Special Product in WTO...