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Enzymatic activity of dust mite allergen extract characterized.
2004 DEC 29 - (NewsRx.com & NewsRx.net) -- The activity of dust mite allergen enzymes has been characterized.
"Enzymatic activity in the fecal droppings from the house dust mite has been postulated to contribute to the elicited allergic response," scientists in California explained.
"Screening dust mite extracts through 137,180 tetrapeptide fluorogenic substrates allowed for the characterization of proteolytic substrate specificity from the potential cysteine and serine proteases in the extract," in a study conducted by J. Harris and coauthors at the Scripps Research Institute in San Diego.
"The extract was further screened against a 4,000 member peptide nucleic acid (PNA) encoded inhibitor library designed to target cysteine proteases using microarray detection," according to the report. "Affinity chromatography coupled with mass spectrometry identified Der p 1 as one of the proteases targeted by the PNA inhibitors in the dust mite lysate."
"A phenotypic readout of Der p 1 function in allergy progression was ...
- Pre-pro sequence needed for DNA vaccine to induce dust mite allergen antibodies.
- Newspaper article from: Immunotherapy Weekly April 16, 2003 700+ words
...for a DNA vaccine encoding the dust mite allergen, Der p 1, to induce...immunogenicity of the major house dust mite allergen Der p 1 following DNA...This article was prepared by Immunotherapy Weekly editors from staff and other...
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- Magazine article from: Environmental Health Perspectives Vojta, Patrick J. Randels, Sandra P. Stout, James Muilenberg, Michael Burge, Harriet A. Henry, Lynn Mitchell, Herman O'Connor, George T. Zeldin, Darryl C. August 1, 2001 700+ words
House dust mite allergen exposure is a postulated risk factor...effectiveness of physical interventions to mitigate house dust mite allergens in this setting. Homes with high levels of house dust mite allergen (Der f 1 + Der p 1 [greater than or...
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- Magazine article from: OB GYN News Kirn, Timothy F. June 1, 2004 700+ words
...publicized studies have suggested that dust mite mattress covers are not effective for...I still tell all my patients about dust mite covers and avoidance," Dr. Freeman...they sought to assess the benefit of dust mite covers as a single intervention--and...
- Dust Mite Covers Effective in Reducing Allergens; Dietary Intervention for...
- Press release article from: PR Newswire October 8, 2004 700+ words
...people who have allergic asthma and use dust mite-impermeable bed covers have improved...patients to determine the effectiveness of dust mite covers in reducing allergy and asthma...intervention group receiving nonpolyurethane dust mite covers, or a placebo group receiving...
- Ready, Set ... Clean! Spring Cleaning Tips From Dyson's; 'Dust Mite Doctor'.
- Press release article from: PR Newswire March 22, 2004 700+ words
...microbiologist David Sykes (a.k.a., "Dust Mite Doctor") offers expert advice on how...dirt and allergen free. According to "Dust Mite Doctor," spring cleaning is a popular...microbiology lab has one of the few pure "House Dust Mite" cultures in the U.K. It is here...
- Ready, Set...Clean! Spring Cleaning Tips from Dyson's 'Dust Mite Doctor'.
- Press release article from: PR Newswire March 26, 2003 700+ words
...microbiologist David Sykes (a.k.a., "Dust Mite Doctor") offers expert advice on how...dirt and allergen free. According to "Dust Mite Doctor," spring cleaning is a popular...microbiology lab has one of the few pure "House Dust Mite" cultures in the U.K. It is here...
- Dust mite, cockroach, cat, and dog allergen concentrations in homes of...
- Magazine article from: Environmental Health Perspectives Leaderer, Brian P. Belanger, Kathleen Triche, Elizabeth Holford, Theodore Gold, Diane R. Kim, Young Jankun, Thomas Ren, Ping McSharry, Jean-ellen Platts-Mills, Thomas A.E. Chapman, Martin D. Bracken, Michael B. April 1, 2002 700+ words
...variations in home concentrations of dust mite, cockroach, cat, and dog allergens...lower and upper cut points for group 1 dust mite ([greater than or equal to] 2.0...portion of homes at the lower cut point for dust mite, cockroach, cat, and dog allergens...
- Giant dust mite to make guest appearance at Seattle area 'Perfect Climate'...
- Press release article from: PR Newswire June 13, 1990 700+ words
...CITY AND ASSIGNMENT DESKS: GIANT DUST MITE TO MAKE GUEST APPEARANCE AT SEATTLE...OPENING WHO: A giant inflatable dust mite (microscopic creature that lives in all homes); a roving, costumed dust mite; a model home wrapped with a giant...